心怀梦想的大龄“胡同公主”樊胜美、大家闺秀闷骚文艺女关雎尔、没头脑和不高兴的综合体邱莹莹，在海市合租一套房，与高智商的海归金领安迪、做事从不按出牌的富二代小妖精曲筱绡，同住在一个名叫“欢乐颂”的中档小区的22楼，五个女人如春兰秋菊，各领风骚，上演着22楼版的“绝望的主妇”，齐心协力地解决了安迪的神秘身世的问题、曲筱绡与同父异母的两个哥哥争家产的问题、樊胜美沉重的家庭负担的问题、邱莹莹的有处女情节的男朋友的问题、关睢尔的警察男友是不是在家庭背景上撒了谎的问题……生活虽然一地鸡毛，但仍要欢歌高进，成长之路虽有玫瑰有荆棘，但什么都不能阻挡坚强的心。
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